Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time

Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time

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Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis.The aim of this study was to determine plasma protein profiles of trained (EET, n=19) and untrained (SED, n=17) individuals at rest and in response to an acute bout of endurance exercise.Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max.Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays.Seventy-eight plasma variables were included in DR. FORMULATED PROBIOTICS ONCE DAILY ULT the final analysis.

Twenty-nine variables displayed significant acute exercise effects in both groups.Seven proteins differed between groups, without being affected by acute exercise.Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals.Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals.An interaction HURRICANE effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers.

The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations.These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.